The evolution of the human dataset relevant to vitamin D safety has been as rapid as that for efficacy. In the past decade, a large number of well-designed human clinical trials have been published involving relatively high doses of vitamin D in a range of populations and subgroups. These data, combined with a general scientific consensus of serum 25(OH)D levels as the marker for vitamin D status, have drastically informed our knowledge regarding the safety of vitamin D. Presented in this publication is an updated risk assessment of vitamin D based on the most recently published human clinical trials.
This review explores the factors that influence nutritional status in older people and describes the physical and cognitive changes that can lead to years of lost good health. It highlights the overwhelming evidence which demonstrates that good nutrition and specific nutrients and other food substances can play a major role in maintaining and enhancing physical and mental performance as well as delaying the onset of chronic diseases. Also available in Spanish.
To fill the needs of regulators and scientific bodies for quantitative safety assessment of bioactive substances, this report details risk assessments performed on a selection of bioactive substances in food. Also available in Japanese.